兔抗IL12RB1多克隆抗体

Background:

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Applications:

ELISA, IHC

Name of antibody:

IL12RB1

Immunogen:

Fusion protein of human IL12RB1

Full name:

interleukin 12 receptor, beta 1

Synonyms：

CD212; IL12RB; IL-12R-BETA1

SwissProt:

P42701

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and human colon cancer

IHC Recommend dilution:

25-100