兔抗DUSP10多克隆抗体

Background:

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus.

Applications:

ELISA, WB, IHC

Name of antibody:

DUSP10

Immunogen:

Fusion protein of human DUSP10

Full name:

dual specificity phosphatase 10

Synonyms：

MKP5; MKP-5

SwissProt:

Q9Y6W6

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human brain and human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

53 kDa

WB Positive control:

Mouse brain tissue

WB Recommended dilution:

200-1000