详情

Background:

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications:

ELISA, IHC

Name of antibody:

ROR1

Immunogen:

Synthetic peptide of human ROR1

Full name:

receptor tyrosine kinase-like orphan receptor 1

Synonyms：

NTRKR1; dJ537F10.1

SwissProt:

Q01973

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human lung cancer and Human prostate cancer

IHC Recommend dilution:

25-100