兔抗BCCIP多克隆抗体

Background:

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Applications:

ELISA, WB

Name of antibody:

BCCIP

Immunogen:

Fusion protein of human BCCIP

Full name:

BRCA2 and CDKN1A interacting protein

Synonyms:

TOK1; TOK-1

SwissProt:

Q9P287

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

36 kDa

WB Positive control:

TM4 cell lysate

WB Recommended dilution:

200-1000