详情

Background:

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.

Applications:

WB

Name of antibody:

IL2RB(Phospho-Tyr364)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 364(Q-G-Y(p)-F-F) derived from Human IL-2Rβ/CD122 .

Full name:

interleukin 2 receptor, beta

Synonyms：

CD122; IL15RB; P70-75

SwissProt:

P14784

WB Predicted band size:

61 kDa

WB Positive control:

COS7 cells lysates

WB Recommended dilution:

500-1000