详情

Background:

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

Applications:

WB

Name of antibody:

EZR(Phospho-Tyr146)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 146 (S-G-Y(p)-L-S) derived from Human Ezrin.

Full name:

ezrin

Synonyms：

CVL; CVIL; VIL2; HEL-S-105

SwissProt:

P15311

WB Predicted band size:

69 kDa

WB Positive control:

293 cells lysates treated with UV

WB Recommended dilution:

500-1000