兔抗STUB1多克隆抗体
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中文名称: 兔抗STUB1多克隆抗体
英文名称:Anti-STUB1 rabbit polyclonal antibody
别 名: STUB1; CHIP; HSPABP2; NY-CO-7; SDCCAG7; UBOX1
相关类别:一抗
储 存: 冷冻(-20℃) 避光
宿 主: Rabbit
抗 原: STUB1
反应种属:Human, Mouse, Rat
标 记 物:Unconjugate
克隆类型:rabbit polyclonal
技术规格
Background: | The carboxy terminus of Hsc70-interacting protein (CHIP, STUB1) is a co-chaperone protein and functional E3 ubiquitin ligase that links the polypeptide binding activity of Hsp70 to the ubiquitin proteasome system. Cytoplasmic CHIP protein contains three 34-amino acid TPR (tetratricopeptide repeat) domains at its amino terminus and a carboxy-terminal U-box domain. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, while E3 ubiquitin ligase activity is confined to the U-box domain. The binding of CHIP to Hsp70 can stall the folding of Hsp70 client proteins and concomitantly facilitate the U-box dependent ubiquitination of Hsp70-bound substrates. CHIP appears to play a central role in cell stress protection and is responsible for the degradation of disease-related proteins that include cystic fibrosis transmembrane conductance regulator, p53, huntingtin and Ataxin-3, Tau protein, and α-synuclein. |
Applications: | WB |
Name of antibody: | STUB1 |
Immunogen: | Fusion protein of human STUB1 |
Full name: | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase |
Synonyms: | STUB1; CHIP; HSPABP2; NY-CO-7; SDCCAG7; UBOX1 |
SwissProt: | Q9UNE7 |
WB Predicted band size: | 35 kDa |
WB Positive control: | HeLa, PC12, COS1, COS7 and OVCAR3 cells, muscle and liver tissue |
WB Recommended dilution: | 500-2000 |