兔抗IGF1R(Phospho-Tyr1161)多克隆抗体

Background:

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Applications:

WB, IHC, IF

Name of antibody:

IGF1R(Phospho-Tyr1161)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 1161(D-I-Y(p)-E-T)derived from Human IGF-1R.

Full name:

insulin-like growth factor 1 receptor

Synonyms：

IGFR; CD221; IGFIR; JTK13

SwissProt:

P08069

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

155 kDa

WB Positive control:

293 cells lysates untreated or treated with insulin

WB Recommended dilution:

500-1000

IF positive control:

MCF7 cells

IF Recommend dilution:

100-200