兔抗CHEK2(Ab-68)多克隆抗体

Background:

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage.

Applications:

WB, IHC

Name of antibody:

CHEK2(Ab-68)

Immunogen:

Synthesized non-phosphopeptide derived from human Chk2 around the phosphorylation site of threonine 68.

Full name:

checkpoint kinase 2

Synonyms：

CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425

SwissProt:

O96017

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

61 kDa

WB Positive control:

Jurkat and Hela cells lysates treated with etoposide 25uM 24hours

WB Recommended dilution:

500-3000