兔抗A多克隆抗体

Background:

TMEM16A, also known as DOG1, ORAOV2, TAOS2 or A (anoctamin 1), is a 986 amino acid multi-pass membrane protein that localizes to both the cell membrane and the cytoplasm and belongs to the anoctamin family. Expressed in a variety of tissues with highest expression in skeletal muscle and liver, TMEM16A functions as a calcium-activated chloride channel that is required for normal tracheal development. Human TMEM16A shares 90% sequence identity with its mouse counterpart, suggesting a conserved role between species. TMEM16A is present in breast, pancreatic, gastric, and uterine cancers, as well as in neck, ovarian and parathyroid tumors, suggesting a role for TMEM16A in carcinogenesis. Three isoforms of TMEM16A exist due to alternative splicing events.

Applications:

ELISA, WB, IHC

Name of antibody:

A

Immunogen:

Synthetic peptide of human A

Full name:

anoctamin 1, calcium activated chloride channel

Synonyms：

DOG1; TAOS2; ORAOV2; TMEM16A

SwissProt:

Q5XXA6

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

114 kDa

WB Positive control:

Human fetal brain tissue

WB Recommended dilution:

200-1000