详情

Background:

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

Applications:

WB, IHC

Name of antibody:

EGFR(Ab-1172)

Immunogen:

Synthesized non-phosphopeptide derived from human EGFR around the phosphorylation site of tyrosine 1172 (P-D-Y(p)-Q-Q).

Full name:

epidermal growth factor receptor

Synonyms：

ERBB; HER1; mENA; ERBB1; PIG61

SwissProt:

P00533

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

134 kDa

WB Positive control:

HT-29 cells lysate

WB Recommended dilution:

500-3000