详情

Background:

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

KCNQ4

Immunogen:

Synthetic peptide of human KCNQ4

Full name:

potassium voltage-gated channel, KQT-like subfamily, member 4

Synonyms：

DFNA2; KV7.4; DFNA2A

SwissProt:

P56696

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human liver cancer and Human brain

IHC Recommend dilution:

50-200

WB Predicted band size:

77 kDa

WB Positive control:

Human fetal brain and mouse brain tissue

WB Recommended dilution:

200-1000