兔抗CTNNB1(Phospho-Ser33)多克隆抗体

Background:

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Applications:

WB, IHC

Name of antibody:

CTNNB1 (Phospho-Ser33)

Immunogen:

Synthetic peptide of human CTNNB1 (Phospho-Ser33)

Full name:

catenin (cadherin-associated protein), beta 1, 88kDa (Phospho-Ser33)

Synonyms：

CTNNB; MRD19; armadillo

SwissProt:

P35222

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

92 kDa

WB Positive control:

MCF-7 cells treated with Calyculin A

WB Recommended dilution:

500-1000