详情

Background:

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint.

Applications:

WB

Name of antibody:

BCR(Phospho-Tyr360)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 360 (T-T-Y(p)-R-M) derived from Human Bcr.

Full name:

breakpoint cluster region

Synonyms：

ALL; CML; PHL; BCR1; D22S11; D22S662

SwissProt:

P11274

WB Predicted band size:

143 kDa

WB Positive control:

COS7 cells lysates

WB Recommended dilution:

500-1000