兔抗CCM2多克隆抗体

Background:

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

CCM2

Immunogen:

Fusion protein of human CCM2

Full name:

CCM2 scaffolding protein

Synonyms:

OSM; C7orf22; PP10187

SwissProt:

Q9BSQ5

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

20-100