兔抗UPF3A多克隆抗体

Background:

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

UPF3A

Immunogen:

Synthetic peptide of human UPF3A

Full name:

UPF3A regulator of nonsense mediated mRNA decay

Synonyms:

UPF3; HUPF3A; RENT3A

SwissProt:

Q9H1J1

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and Human lung cancer

IHC Recommend dilution:

20-100