兔抗ALPL多克隆抗体

Background:

This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.

Applications:

ELISA, IHC

Name of antibody:

ALPL

Immunogen:

Fusion protein of human ALPL

Full name:

alkaline phosphatase, biomineralization associated

Synonyms:

HOPS; TNAP; TNALP; APTNAP; TNSALP; AP-TNAP

SwissProt:

P05186

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and Human liver cancer

IHC Recommend dilution:

200-400