兔抗ERBB2(Phospho-Tyr1112)多克隆抗体

Background:

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here.

Applications:

WB

Name of antibody:

ERBB2(Phospho-Tyr1112)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 1112 (Q-R-Y(p)-S-E) derived from Human HER2.

Full name:

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

Synonyms：

NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu

SwissProt:

P04626

WB Predicted band size:

138 kDa

WB Positive control:

HepG2 cells lysates

WB Recommended dilution:

500-1000